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Hey so I had to upgrade to MOJAVE for other reasons and noticed last night that ME (ver 2 or 3) would cause Serato Pro to come to a slow halt and sometimes freeze altogether.
I ended up doing a clean install of Mojave and the same was happening. What i noticed is I do not have this issue when ME isn't running. When ME is connected I start to get some stuttering. When connected via HDMI that's when things get worst.
At the moment it seems that if ME is on the same screen as Serato Pro the issues happen. I did some test for about 2 hours with ME on it own desktop and Serato on its own desktop and all my playback and samples seem to be stable. This was never an issue when I was on Yosemite. Any thoughts on what could be the culprit now with Mojave?